ICD code definitions

CPT® Code 96369: Intravenous Infusion, Therapeutic, Prophylactic, or Diagnostic, Administration of Drugs, Substances, or Biologicals

May 16, 2025
3 min read
CPT® Code 96369

Infusion for therapeutic, prophylactic, or diagnostic purposes

CPT® Code 96369 is used to report the administration of intravenous (IV) infusion therapy for therapeutic, prophylactic, or diagnostic purposes. This code specifically applies to the administration of drugs, substances, or biologicals that are provided through an IV infusion lasting more than 1 hour.

When to use CPT® Code 96369

This code is applicable when:

  • The patient receives IV infusion therapy for therapeutic, prophylactic, or diagnostic purposes.
  • The infusion lasts more than 1 hour but is less than 8 hours in duration.
  • The infusion is for a single drug, substance, or biological agent.
  • The provider administers the infusion in the outpatient setting or in a similar clinical setting.

CPT 96369 applies to IV infusions given for a variety of reasons, including administering medications like antibiotics, chemotherapy, biologic therapies, or other therapeutic agents to manage a patient's condition. It is also used when prophylactic treatments are provided (e.g., vaccinations, preventive medications) or diagnostic infusions (such as contrast media for diagnostic imaging) are needed.

Administration and time requirements

For CPT 96369 to be appropriate, the following conditions must be met:

  • The infusion is administered over 1 hour or longer.
  • The duration of the IV infusion (from start to finish) must be documented accurately. The provider must also note the specific drug or biological being administered.
  • Additional infusions for the same or other drugs can be billed with an appropriate modifier (e.g., 96368 for additional sequential IV infusion of a different substance).

Documentation must specify:

  • The total time spent administering the infusion (time must be noted for the encounter).
  • The medication or substances used during the infusion.
  • Any related services, such as patient monitoring or clinical observations during the infusion process.

Key documentation tips

  • Document the infusion time clearly, including both start and end times of the infusion. If the infusion extends over a period, provide details of the infusion’s start and finish, including any intervals of pauses or breaks.
  • Record the specific substance or drug administered via the infusion. This is essential to distinguish between types of infusions (therapeutic vs. diagnostic).
  • Include any clinical monitoring done during the infusion (e.g., vital signs, adverse reactions), as this may affect the complexity of the service.
  • If a subsequent or additional infusion is administered, use appropriate coding (e.g., 96368 for additional infusions).

How OptiMantra supports accurate coding for CPT® 96369

OptiMantra is a comprehensive practice management system that simplifies the documentation and billing processes for complex procedures, including intravenous infusions like those billed under CPT 96369. OptiMantra helps practices by:

  • Automated time tracking to ensure accurate documentation of the time spent on the infusion, including start and stop times.
  • Real-time coding suggestions to help providers choose the correct codes based on the substances administered and the length of the infusion.
  • Comprehensive EHR templates designed to guide providers through the required documentation, ensuring all necessary details (e.g., infusion substance, duration, monitoring) are captured.
  • Seamless billing integration, ensuring that the coding matches the clinical documentation and streamlining the submission process for claims.
  • Audit trail functionality to keep detailed, time-stamped logs of each encounter, protecting the practice during payer audits.

By utilizing OptiMantra, healthcare providers can confidently code for infusion services like CPT 96369, reducing the risk of errors, improving efficiency, and ensuring compliance with payer requirements.

Try OptiMantra for free here!

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.

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